Systematic review: the management of chronic diarrhoea due to bile acid malabsorption

  title={Systematic review: the management of chronic diarrhoea due to bile acid malabsorption},
  author={Claire E. Wilcox and Jeff K Turner and John T. Green},
  journal={Alimentary Pharmacology \& Therapeutics},
Bile acid malabsorption (BAM) is a common, yet under‐recognised, cause of chronic diarrhoea, with limited guidance available on the appropriate management of patients with BAM. 

Systematic review with meta‐analysis: the prevalence of bile acid malabsorption and response to colestyramine in patients with chronic watery diarrhoea and previous cholecystectomy

A limited number of small‐sized studies suggest that bile acid diarrhoea is frequent in patients with chronic watery diarrhoea and previous cholecystectomy.

Chronic diarrhoea due to bile salt malabsorption: nurse-led assessment, medical treatment and dietary management

Bile salt malabsorption (BSM) occurs when bile salts, which are secreted in the small bowel to aid digestion of fats and vitamins, are not sufficiently re-absorbed in the terminal ileum. Consequent...

Does your patient have bile acid malabsorption

The synthesis, enterohepatic circulation, and function of bile acids are briefly reviewed followed by a discussion of biles acid malabsorption.

Long‐term effect of medical treatment of diarrhoea in 377 patients with SeHCAT scan diagnosed bile acid malabsorption from 2003 to 2016; a retrospective study

Diagnosis is possible by measuring the retention fraction of orally ingested 75Selenium homotaurocholic acid (SeHCAT), which indicates excessive amounts of bile acids entering the colon due to bile Acid malabsorption cause chronic bile acid diarrhoea.

Randomised clinical trial: colestyramine vs. hydroxypropyl cellulose in patients with functional chronic watery diarrhoea

Idiopathic bile acid malabsorption (BAM) has been suggested as a cause of chronic watery diarrhoea, with a response to colestyramine in 70% of patients. However, the efficacy of this drug has never

Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea‐predominant irritable bowel syndrome

About one‐third of patients with IBS‐diarrhoea (irritable bowel syndrome‐D) have evidence of increased bile acid synthesis or excretion.

Bile Acid Malabsorption / Diarrhoea

  • Medicine
  • 2016
Igiopathic BAM (no obvious cause) occurs in both men and women, mostly between the ages of 30 and 70, sometimes lasting longer than 10 years.

Food, fibre, bile acids and the pelvic floor: An integrated low risk low cost approach to managing irritable bowel syndrome.

Patients presenting with abdominal pain and diarrhea are often labelled as suffering from irritable bowel syndrome, and medications may be used often without success. Advances in the understanding of

Prevalence and clinical features of bile acid diarrhea in patients with chronic diarrhea

Evaluated the prevalence of bile acid diarrhea in patients consecutively evaluated for chronic diarrhea in an Outpatient Gastroenterology Clinic.

Letter: bile acid malabsorption – what is the prevalence in patients with chronic diarrhoea?

The findings highlight the importance of systematically evaluating patients with chronic diarrhoea, with an organic condition identified in 27% and how BAM prevalence may be similar to a well-established condition such as coeliac disease.



Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea‐predominant irritable bowel syndrome

Recurrent, watery diarrhoea affects one‐third of patients diagnosed with irritable bowel syndrome and Idiopathic bile acid malabsorption (‘I‐BAM’) may be the cause.

Idiopathic bile acid malabsorption: qualitative and quantitative clinical features and response to cholestyramine

The SeHCAT (75Selenium HomotauroCholic Acid Test) can accurately diagnoseiopathic bile acid malabsorption and help identify and treat chronic diarrhoea.

Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea

Yield of 23‐seleno‐25‐homo‐tauro‐cholic acid (SeHCAT) scanning in chronic diarrhea patients is examined, and predictors of a positive test are attempted to identify.

Bile acid malabsorption in persistent diarrhoea.

It is indicated that BAM is common in patients with chronic diarrhoea, and is frequently found in IBS, and the results of open treatment suggest that, where antidiarrhoeal drugs fail in such patients, BAS are often effective.

Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention

It is shown patients with bile acid diarrhoea have lower median levels compared with healthy controls, of the ileal hormone fibroblast growth factor 19 (FGF19), which regulates bile Acid synthesis.

Recent advances in the understanding of bile acid malabsorption.

Improvements in the recognition of the condition and optimization of treatment are required, and evidence is accumulating that BAM is more prevalent than first thought.

Bile acid malabsorption in patients with chronic diarrhoea.

  • S. Eusufzai
  • Medicine
    Scandinavian journal of gastroenterology
  • 1993
The results suggest that bile acid malabsorption may be common in chronic diarrhoea patients but may not always be the primary cause of diarrhoeA.

Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention.

The cause of intractable chronic diarrhoea was found to be malabsorption of bile acid in five out of 42 patients thought to have the irritable bowel syndrome, six out of 29 patients with persistent

Bile acid malabsorption in patients with chronic diarrhoea: clinical value of SeHCAT test.

The SeHCAT test is of value in evaluation of patients with chronic diarrhoea as a second-line investigation with a high diagnostic yield and seems to predict the benefit of treatment with cholestyramine.

Prognosis of adult-onset idiopathic bile acid malabsorption.

The study confirms the reliability of the SeHCAT test in diagnosing IBAM, which shows that despite adult onset of symptoms, only a few patients improve after several years' observation.