Systematic review: the management of chronic diarrhoea due to bile acid malabsorption

@article{Wilcox2014SystematicRT,
  title={Systematic review: the management of chronic diarrhoea due to bile acid malabsorption},
  author={Claire E. Wilcox and Jeff K Turner and John T. Green},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2014},
  volume={39}
}
Bile acid malabsorption (BAM) is a common, yet under‐recognised, cause of chronic diarrhoea, with limited guidance available on the appropriate management of patients with BAM. 

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TLDR
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...

References

SHOWING 1-10 OF 63 REFERENCES

Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea‐predominant irritable bowel syndrome

TLDR
Recurrent, watery diarrhoea affects one‐third of patients diagnosed with irritable bowel syndrome and Idiopathic bile acid malabsorption (‘I‐BAM’) may be the cause.

Idiopathic bile acid malabsorption: qualitative and quantitative clinical features and response to cholestyramine

TLDR
The SeHCAT (75Selenium HomotauroCholic Acid Test) can accurately diagnoseiopathic bile acid malabsorption and help identify and treat chronic diarrhoea.

Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea

TLDR
Yield of 23‐seleno‐25‐homo‐tauro‐cholic acid (SeHCAT) scanning in chronic diarrhea patients is examined, and predictors of a positive test are attempted to identify.

Bile acid malabsorption in persistent diarrhoea.

TLDR
It is indicated that BAM is common in patients with chronic diarrhoea, and is frequently found in IBS, and the results of open treatment suggest that, where antidiarrhoeal drugs fail in such patients, BAS are often effective.

Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention

TLDR
It is shown patients with bile acid diarrhoea have lower median levels compared with healthy controls, of the ileal hormone fibroblast growth factor 19 (FGF19), which regulates bile Acid synthesis.

Recent advances in the understanding of bile acid malabsorption.

TLDR
Improvements in the recognition of the condition and optimization of treatment are required, and evidence is accumulating that BAM is more prevalent than first thought.

Bile acid malabsorption in patients with chronic diarrhoea.

  • S. Eusufzai
  • Medicine
    Scandinavian journal of gastroenterology
  • 1993
TLDR
The results suggest that bile acid malabsorption may be common in chronic diarrhoea patients but may not always be the primary cause of diarrhoeA.

Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention.

The cause of intractable chronic diarrhoea was found to be malabsorption of bile acid in five out of 42 patients thought to have the irritable bowel syndrome, six out of 29 patients with persistent

Bile acid malabsorption in patients with chronic diarrhoea: clinical value of SeHCAT test.

TLDR
The SeHCAT test is of value in evaluation of patients with chronic diarrhoea as a second-line investigation with a high diagnostic yield and seems to predict the benefit of treatment with cholestyramine.

Prognosis of adult-onset idiopathic bile acid malabsorption.

TLDR
The study confirms the reliability of the SeHCAT test in diagnosing IBAM, which shows that despite adult onset of symptoms, only a few patients improve after several years' observation.
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