Systematic review: noncoeliac gluten sensitivity

@article{MolinaInfante2015SystematicRN,
  title={Systematic review: noncoeliac gluten sensitivity},
  author={Javier Molina-Infante and Santos Santolaria and David S. Sanders and Fernando Fern{\'a}ndez-Ba{\~n}ares},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2015},
  volume={41}
}
Noncoeliac gluten sensitivity (NCGS) is a controversial emerging disorder. Despite reported symptoms related to the ingestion of gluten, NCGS remains a diagnosis based on the exclusion of coeliac disease, given the absence of reliable biomarkers. 
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88 Citations
Highly Influential Citations
6
Background Citations
36
Results Citations
5

88 Citations

Non-coeliac gluten sensitivity and reproductive disorders
TLDR
This case highlights a possible role of treating NCGS in the reversal of infertility, and the information related to non-coeliac gluten sensitivity (NCGS) and infertility is lacking.
Randomised clinical study: gluten challenge induces symptom recurrence in only a minority of patients who meet clinical criteria for non‐coeliac gluten sensitivity
It is unknown whether symptoms in non‐coeliac patients (non‐CD) meeting clinical diagnostic criteria for noncoeliac gluten sensitivity (NCGS) are specifically triggered by gluten.
Non Celiac Gluten Sensitivity
TLDR
Direct implication of gluten in the onset of symptoms is often unproved as a low fermentable oligo-, di- and mono-saccharides and polyols diet or other components of cereals as wheat amylase trypsin inhibitor could be similarly involved.
Duodenal histological features in suspected non-celiac gluten sensitivity: new insights into a still undefined condition
TLDR
This study retrospectively evaluated duodenal biopsies of a cohort of patients undergoing clinical diagnostic algorithm for NCGS and suggested the presence of a gluten-induced gut epithelial cell damage with a compromised intestinal permeability.
Non‐coeliac gluten sensitivity
TLDR
In the absence of clarity in its diagnosis, the epidemiology, prognosis, and therapeutic approaches to a patient who may be gluten sensitive remain to be determined.
[Non-celiac Gluten Sensitivity].
  • R. Cha, Hyun Jin Kim
  • Medicine
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • 2020
TLDR
New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS.
Non-coeliac gluten sensitivity and the spectrum of gluten-related disorders: an updated overview
TLDR
There is inconsistent evidence when evaluating the effects of a gluten challenge in patients with suspected NCGS and there is a need for a standardised procedure to confirm the diagnosis, ultimately enabling the optimisation of clinical care.
Non-Celiac Gluten Sensitivity in Children: Controversial Role of Gluten and Diagnostic Enigma
TLDR
The present review evaluates the published studies based largely on the adult population and describes the key elements in diagnosing NCGS and differential diagnosis with CD and WA.
Diagnostic Dilemma, Possible Non-celiac Gluten Sensitivity: Consideration in Approach and Management
TLDR
Considering gluten-related disorders are rising and not much is known about NCGS, this case is presented to create awareness and raise questions regarding diagnosis, need for specific monitoring and implications on the management.
Coeliac Disease and Non-coeliac Gluten Sensitivity: A Clinical and Philosophical Discussion
TLDR
These approaches, which lie behind many nosological and taxonomic discussions in medicine, are analysed and it is shown that this characteristic is not exclusive to psychiatry.
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References

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Randomised clinical trial: gluten may cause depression in subjects with non‐coeliac gluten sensitivity – an exploratory clinical study
Current evidence suggests that many patients with self‐reported non‐coeliac gluten sensitivity (NCGS) retain gastrointestinal symptoms on a gluten‐free diet (GFD) but continue to restrict gluten as…
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Mutatis mutandis: are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report.
TLDR
The reported cases suggest the precious potential role that organ culture systems may play in differentiating CD from NCGS and this method should be recommended when gluten-related disorders are suspected in order to reduce the inappropriate diagnosis of NCGS.
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TLDR
In the absence of clarity in its diagnosis, the epidemiology, prognosis, and therapeutic approaches to a patient who may be gluten sensitive remain to be determined.
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TLDR
Twenty patients with FM without CD who improved when placed on a gluten-free diet are described, supporting the hypothesis that non-celiac gluten sensitivity may be an underlying cause of FM syndrome.
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TLDR
This prospective survey shows that non-celiac gluten sensitivity has a strong correlation with female gender and adult age, and the prevalence of NCGS seems to be only slightly higher than that of celiac disease.
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TLDR
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TLDR
Just over 1 in 4 respondents self-reporting as nonceliac gluten sensitivity fulfill criteria for its diagnosis, suggesting initiation of a GFD without adequate exclusion of celiac disease is common.
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TLDR
Patients complain of IBS-like symptoms and extraintestinal manifestations that occur shortly after the ingestion of gluten, and symptoms improve or disappear when gluten is withdrawn from the diet, and recur if gluten is reintroduced.
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