Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy

  title={Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy},
  author={Bariş O. Yildirim and Jan Derksen},
  journal={Neuroscience \& Biobehavioral Reviews},

Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy

Evidence is insufficient to suggest a largely biological etiology for the disorder, but information from developmental and epigenetic research may suggest complex, multidimensional trajectories for individuals experiencing psychopathy.

The role of the serotonin transporter gene, brain structure and family environment in the emergence of depression during adolescence

This thesis aims to enhance current understanding of this interaction by considering how two different dimensions of environmental experience (threat versus deprivation) might interact with the serotonin transporter gene during adolescence, while also investigating potential underlying neurobiological mechanisms.

Underlying Mechanisms of Gene–Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms

It is argued that one way to help resolve the problem is the development of theory-driven a priori hypotheses on which biopsychosocial mechanisms might underlie cG × E, and three possible explanatory mechanisms are described, based on extant literature on the concepts of emotional reactivity, reward sensitivity, and punishment sensitivity.

Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents

The presence of the G allele of rs6318 was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found with heterozygosis in females, which contribute to the identification of mental and behavioral phenotypes associated with gene expression.

Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies

In the largest study of this polymorphism, it is determined that rs6318 is not associated with depression, or BMI, and a random effects meta-analysis was conducted to examine whether the Cys23Ser variant was associated with depressive symptoms and body mass index (BMI).

The Validity of Primary and Secondary Subtypes of Psychopathy in Children and Adolescents

Characterized by atypical behavioral (e.g., antisociality), interpersonal (e.g., egocentricity), and affective facets (e.g., low remorse), the phenomenological diversity of psychopathy likely

A complete overview of cG 9 E in externalizing behaviors is missing ( for a general overview of cG 9 E in psychopathology see

Over the last decade, several candidate genes (i.e., MAOA, DRD4, DRD2, DAT1, 5-HTTLPR, and COMT) have been extensively studied as potential moderators of the detrimental effects of postnatal family

Psychopathy and Biosocial Criminology

The chapter examines psychopathy and its relation to biosocial criminology. The chapter advances that psychopathy facilitates emerging biosocial explanations of antisocial behavior. Several features



Analysis of monoaminergic genes, childhood abuse, and dimensions of psychopathy.

It is found that the emotional deficits characterizing the affective factor of psychopathy, as measured by the Psychopathy Checklist: Screening Version, were highest among carriers of the 5-HTT long allele, and the impulsive and irresponsible lifestyle features of Psychopathy were higher among low-activity than high-activity MAO-A carriers.

A gene–environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder

  • C. JacobT. Nguyen A. Reif
  • Psychology, Biology
    European Archives of Psychiatry and Clinical Neuroscience
  • 2009
Main effects as well as main effects of 5-HTT-LPR and the TPH2 SNP rs4570625 on the occurrence of personality disorders are observed and a G × E interaction term is taken into account, since this approach may better fit the data indicating that the effect of a gene is modified by stressful life events or, vice versa, that stressfulLife events only have an effect in the presence of a susceptibility genotype.

Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature.

Some of the recent molecular genetics work concerning antisocial spectrum disorders and psychopathy is summarized, with a focus on genes involved in the serotonergic and dopaminergic pathways, while also mentioning some of the novel genetic factors being considered.

Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources.

Preliminary results that the l/l genotype confers risk for the emotional deficits and predatory interpersonal traits associated with psychopathy among youths raised in disadvantaged environments are provided.

The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism.

Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity

The results suggest that specific gene variants influence psychopathy traits in ADHD by being associated with ‘emotional dysfunction’ scores.

The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population

The results suggest that CACNA1C is involved in the genetic architecture of endophenotypes for affective disorders and schizophrenia, and that it shows a distinct sex-specific effect.

Serotonin, genetic variability, behaviour, and psychiatric disorders - a review

The hypothesis that the dual role of serotonin as a neurotransmitter and a neurotrophic factor has a significant impact on behaviour and risk for neuropsychiatric disorders through altered development of limbic neurocircuitry involved in emotional processing, and development of the serotonergic neurons, during early brain development is explored.