Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy

@article{Yildirim2013SystematicRS,
  title={Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy},
  author={Bariş O. Yildirim and Jan Derksen},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2013},
  volume={37},
  pages={1254-1296}
}
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69 Citations
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69 Citations

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References

SHOWING 1-10 OF 771 REFERENCES

Analysis of monoaminergic genes, childhood abuse, and dimensions of psychopathy.

TLDR
It is found that the emotional deficits characterizing the affective factor of psychopathy, as measured by the Psychopathy Checklist: Screening Version, were highest among carriers of the 5-HTT long allele, and the impulsive and irresponsible lifestyle features of Psychopathy were higher among low-activity than high-activity MAO-A carriers.

A gene–environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder

  • C. JacobT. Nguyen A. Reif
  • Psychology, Biology
    European Archives of Psychiatry and Clinical Neuroscience
  • 2009
TLDR
Main effects as well as main effects of 5-HTT-LPR and the TPH2 SNP rs4570625 on the occurrence of personality disorders are observed and a G × E interaction term is taken into account, since this approach may better fit the data indicating that the effect of a gene is modified by stressful life events or, vice versa, that stressfulLife events only have an effect in the presence of a susceptibility genotype.

Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature.

TLDR
Some of the recent molecular genetics work concerning antisocial spectrum disorders and psychopathy is summarized, with a focus on genes involved in the serotonergic and dopaminergic pathways, while also mentioning some of the novel genetic factors being considered.

Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources.

TLDR
Preliminary results that the l/l genotype confers risk for the emotional deficits and predatory interpersonal traits associated with psychopathy among youths raised in disadvantaged environments are provided.

Imaging Genetics: Perspectives from Studies of Genetically Driven Variation in Serotonin Function and Corticolimbic Affective Processing

The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism.

Psychopathic personality or personalities? Exploring potential variants of psychopathy and their implications for risk assessment

Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity

TLDR
The results suggest that specific gene variants influence psychopathy traits in ADHD by being associated with ‘emotional dysfunction’ scores.

The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population

TLDR
The results suggest that CACNA1C is involved in the genetic architecture of endophenotypes for affective disorders and schizophrenia, and that it shows a distinct sex-specific effect.

Serotonin, genetic variability, behaviour, and psychiatric disorders - a review

TLDR
The hypothesis that the dual role of serotonin as a neurotransmitter and a neurotrophic factor has a significant impact on behaviour and risk for neuropsychiatric disorders through altered development of limbic neurocircuitry involved in emotional processing, and development of the serotonergic neurons, during early brain development is explored.
...