Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia

  title={Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia},
  author={Am{\'e}lie Piton and Julie L Gauthier and Fadi Hamdan and Ronald G. Lafreni{\'e}re and Yuming Yang and Edouard Henrion and Sandra Laurent and Anne Noreau and Pascale Thibodeau and Liliane Karemera and Dan Spiegelman and F Kuku and Jeremy Duguay and Laurie Destroismaisons and P. Jolivet and M{\'e}lanie C{\^o}t{\'e} and Karine Lachapelle and Oumarou Foly Diallo and Alice Raymond and Claude Marineau and Nathalie Champagne and Lan Xiong and Claudia Gaspar and J B Rivi{\`e}re and Julien Tarabeux and Patrick Cossette and M O Krebs and Judith L. Rapoport and Anjene Addington and Lynn E. DeLisi and Laurent Mottron and Ridha Joober and E. J. Fombonne and Pierre Drapeau and Guy Rouleau},
  journal={Molecular Psychiatry},
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions in a fraction of cases. In addition, for both disorders, males are either more significantly or more severely affected than females, which may be explained in part by X-linked… CONTINUE READING
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