Systematic protein–protein interaction mapping for clinically relevant human GPCRs

  title={Systematic protein–protein interaction mapping for clinically relevant human GPCRs},
  author={Kate Sokolina and Saranya Kittanakom and Jamie D. Snider and Max Kotlyar and Pascal Maurice and Jorge Gand{\'i}a and Abla Benleulmi-Chaachoua and Kenjiro Tadagaki and Atsuro Oishi and V. Wong and Ramy Habashy Malty and Viktor Deineko and Hiroyuki Aoki and Shahreen Amin and Zhong Yao and Xavier Morat{\'o} and David Otasek and Hiroyuki Kobayashi and Javier Men{\'e}ndez and Daniel Auerbach and St{\'e}phane Angers and Natasa Przulj and Michel Bouvier and Mohan Babu and Francisco Ciruela and Ralf Jockers and Igor Jurisica and Igor Stagljar},
  booktitle={Molecular systems biology},
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) approach and identified interacting partners for 48 selected full… CONTINUE READING



Citations per Year

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