Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression

  title={Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression},
  author={Evangelos Vassos and David A. Collier and Seena Fazel},
  journal={Molecular Psychiatry},
  pages={471 - 477}
A large number of candidate gene studies for aggression and violence have been conducted. Successful identification of associations between genetic markers and aggression would contribute to understanding the neurobiology of antisocial behavior and potentially provide useful tools for risk prediction and therapeutic targets for high-risk groups of patients and offenders. We systematically reviewed the literature and assessed the evidence on genetic association studies of aggression and related… 

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The Broad Antisocial Behavior Consortium entails the largest collaboration to date on the genetic architecture of ASB, and the first results suggest that ASB may be highly polygenic and has potential heterogeneous genetic effects across sex.

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Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM

  • Y. Zhang‐JamesS. Faraone
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2016
This work examined all aggression phenotypes catalogued in Online Mendelian Inheritance in Man, an Online Catalog of Human Genes and Genetic Disorders, and identified 95 human disorders that have documented aggressive symptoms in at least one individual with a well‐defined genetic variant.



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A review of effective interventions for reducing aggression and violence

  • J. Mcguire
  • Psychology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2008
There is sufficient evidence currently available to substantiate the claim that personal violence can be reduced by psychosocial interventions, but that much more research is required to delineate the parameters of effectiveness in this context.

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A meta-analysis was performed on data from 24 genetically informative studies by using various personality measures of aggression. There was a strong overall genetic effect that may account for up to

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