Systematic localization of Oct-3/4 to the gastrulating mouse conceptus suggests manifold roles in mammalian development.

@article{Downs2008SystematicLO,
  title={Systematic localization of Oct-3/4 to the gastrulating mouse conceptus suggests manifold roles in mammalian development.},
  author={Karen Marina Gonz{\'a}lez Downs},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 2},
  pages={
          464-75
        }
}
Oct-3/4 was localized to the mouse conceptus between the onset of gastrulation and 16-somite pairs (-s; approximately 6.5-9.25 days postcoitum, dpc). Results revealed Oct-3/4 in a continuum of morphologically distinct epiblast-derived embryonic and extraembryonic tissues. In the allantois, distal-to-proximal diminution in the Oct-3/4 domain over time and co-localization with Flk-1 in angioblasts accorded with a role in vascular differentiation and the presence of a stem cell reservoir. In… CONTINUE READING
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