Systematic isolation of microbial metabolites for natural products depository (NPDepo)

@article{Osada2011SystematicIO,
  title={Systematic isolation of microbial metabolites for natural products depository (NPDepo)},
  author={Hiroyuki Osada and Toshihiko Nogawa},
  journal={Pure and Applied Chemistry},
  year={2011},
  volume={84},
  pages={1407 - 1420}
}
A microbial fraction library has been constructed as a part of RIKEN Natural Products Depository (NPDepo) to discover and isolate novel metabolites with unique biological activity from microbial sources efficiently and rapidly. The fraction library was made by a systematic separation method based on basic chromatographic techniques. Each fraction in the library was analyzed by liquid chromatography/mass spectrometry (LC/MS) to reveal physicochemical properties of each metabolite within the… 

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