Systematic interpretation of comutated genes in large-scale cancer mutation profiles.

@article{Gu2010SystematicIO,
  title={Systematic interpretation of comutated genes in large-scale cancer mutation profiles.},
  author={Yunyan Gu and Da Rui Yang and Jinfeng Zou and Wencai Ma and Ruihong Wu and Wenyuan Zhao and Yuannv Zhang and Hui Xiao and Xue Gong and Min Zhang and Jing li Zhu and Zheng Guo},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 8},
  pages={
          2186-95
        }
}
By high-throughput screens of somatic mutations of genes in cancer genomes, hundreds of cancer genes are being rapidly identified, providing us abundant information for systematically deciphering the genetic changes underlying cancer mechanism. However, the functional collaboration of mutated genes is often neglected in current studies. Here, using four genome-wide somatic mutation data sets and pathways defined in various databases, we showed that gene pairs significantly comutated in cancer… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Combinatorial patterns of somatic gene mutations in cancer.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Improved scoring of functional Mol Cancer Ther

A Alexa, J Rahnenfuhrer, T. Lengauer
  • Published OnlineFirst July
  • 2010
VIEW 1 EXCERPT