Systematic identification of splice variants in human P/Q-type channel alpha1(2.1) subunits: implications for current density and Ca2+-dependent inactivation.

@article{Soong2002SystematicIO,
  title={Systematic identification of splice variants in human P/Q-type channel alpha1(2.1) subunits: implications for current density and Ca2+-dependent inactivation.},
  author={Tuck Wah Soong and Carla D. DeMaria and Rebecca Alvania and Larry S Zweifel and Mui Cheng Liang and Scott Mittman and William S. Agnew and David T. Yue},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 23},
  pages={10142-52}
}
P/Q-type (Ca(v)2.1) calcium channels support a host of Ca2+-driven neuronal functions in the mammalian brain. Alternative splicing of the main alpha1A (alpha1(2.1)) subunit of these channels may thereby represent a rich strategy for tuning the functional profile of diverse neurobiological processes. Here, we applied a recently developed "transcript-scanning" method for systematic determination of splice variant transcripts of the human alpha1(2.1) gene. This screen identified seven loci of… CONTINUE READING
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Systematic determination of splice variation in human P/Q-type

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Three new alternative spliced exons of the calcium channel a 1 B subunit gene CACNA 1 B

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