Systematic identification of regulatory elements in conserved 3' UTRs of human transcripts.

@article{Oikonomou2014SystematicIO,
  title={Systematic identification of regulatory elements in conserved 3' UTRs of human transcripts.},
  author={Panos Oikonomou and Hani Goodarzi and Saeed Tavazoie},
  journal={Cell reports},
  year={2014},
  volume={7 1},
  pages={
          281-92
        }
}
Posttranscriptional regulatory programs governing diverse aspects of RNA biology remain largely uncharacterized. Understanding the functional roles of RNA cis-regulatory elements is essential for decoding complex programs that underlie the dynamic regulation of transcript stability, splicing, localization, and translation. Here, we describe a combined experimental/computational technology to reveal a catalog of functional regulatory elements embedded in 3' UTRs of human transcripts. We used a… CONTINUE READING
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