Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.

  title={Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.},
  author={Mohini Rajasagi and Sachet Ashok Shukla and Edward F. Fritsch and Derin B. Keskin and David S. DeLuca and Ellese M. Carmona and Wandi Zhang and Carrie L. Sougnez and Kristian Cibulskis and John Sidney and Kristen E. Stevenson and Jerome Ritz and Donna S Neuberg and Vladimir Brusic and Stacey Bolk Gabriel and Eric S. Lander and Gad Getz and Nir Hacohen and Catherine J. Wu},
  volume={124 3},
Genome sequencing has revealed a large number of shared and personal somatic mutations across human cancers. In principle, any genetic alteration affecting a protein-coding region has the potential to generate mutated peptides that are presented by surface HLA class I proteins that might be recognized by cytotoxic T cells. To test this possibility, we implemented a streamlined approach for the prediction and validation of such neoantigens derived from individual tumors and presented by patient… CONTINUE READING
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Melanomas acquire resistance to B-RAF(V600E) inhibition by BLOOD, 17 JULY 2014 x VOLUME 124, NUMBER 3 NEOANTIGENS FOR PERSONALIZED IMMUNOTHERAPY

  • R Nazarian, H Shi, Q Wang
  • For personal use only. on May
  • 2015

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