Systematic identification of pathological lamin A interactors

@inproceedings{Dittmer2014SystematicIO,
  title={Systematic identification of pathological lamin A interactors},
  author={Travis Alan Dittmer and Nidhi Sahni and Nard Kubben and David E Hill and Marc Vidal and Rebecca C. Burgess and Vassilis Roukos and Tom Misteli},
  booktitle={Molecular biology of the cell},
  year={2014}
}
Laminopathies are a collection of phenotypically diverse diseases that include muscular dystrophies, cardiomyopathies, lipodystrophies, and premature aging syndromes. Laminopathies are caused by >300 distinct mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural elements of the mammalian cell nucleus. The genotype-phenotype relationship and the basis for the pronounced tissue specificity of laminopathies are poorly understood… CONTINUE READING
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