Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells.

@article{Woerner2001SystematicIO,
  title={Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells.},
  author={Stefan M. Woerner and Johannes Gebert and Yan P. Yuan and Christian Sutter and Ruediger Ridder and Peer Bork and Magnus von Knebel Doeberitz},
  journal={International journal of cancer},
  year={2001},
  volume={93 1},
  pages={12-9}
}
Microsatellite instability (MSI) caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome but is also found in about 15% of all sporadic tumors. Most affected microsatellites reside in untranslated intergenic or intronic sequences. However, recently few genes with coding microsatellites were also shown to be mutational targets in MSI-positive cancers and might represent important mutation targets in… CONTINUE READING

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