Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs.

@article{Kosugi2009SystematicIO,
  title={Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs.},
  author={Shunichi Kosugi and Masako Hasebe and Masaru Tomita and Hiroshi Yanagawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 25},
  pages={10171-6}
}
The cell cycle-dependent nucleocytoplasmic transport of proteins is predominantly regulated by CDK kinase activities; however, it is currently difficult to predict the proteins thus regulated, largely because of the low prediction efficiency of the motifs involved. Here, we report the successful prediction of CDK1-regulated nucleocytoplasmic shuttling proteins using a prediction system for nuclear localization signals (NLSs). By systematic amino acid replacement analyses in budding yeast, we… CONTINUE READING
Highly Influential
This paper has highly influenced 37 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
275 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 275 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

- regulated , dosage suppressor of drc 1 / sld 2 and dpb 11 mutants

  • Z Zhu, WH Chung, EY Shim, SE Lee, G Ira
  • Cell Cycle
  • 2008

Similar Papers

Loading similar papers…