Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.

@article{Zhang2007SystematicIO,
  title={Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.},
  author={Liang Zhang and Lei Ding and Tom Hiu Tung Cheung and Meng-Qiu Dong and Jun Chen and Aileen K. Sewell and Xuedong Liu and John R. Yates and Min Han},
  journal={Molecular cell},
  year={2007},
  volume={28 4},
  pages={
          598-613
        }
}
MicroRNAs (miRNAs) regulate gene expression for diverse functions, but only a limited number of mRNA targets have been experimentally identified. We show that GW182 family proteins AIN-1 and AIN-2 act redundantly to regulate the expression of miRNA targets, but not miRNA biogenesis. Immunoprecipitation (IP) and mass spectrometry indicate that AIN-1 and AIN-2 interact only with miRNA-specific Argonaute proteins ALG-1 and ALG-2 and with components of the core translational initiation complex… CONTINUE READING
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