Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.

@article{Song2018SystematicGI,
  title={Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.},
  author={Wan Young Song and N{\'o}ra Zsindely and Anik{\'o} Farag{\'o} and J. Lawrence Marsh and L{\'a}szl{\'o} Bodai},
  journal={Human molecular genetics},
  year={2018},
  volume={27 4},
  pages={759}
}
Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby preventing or facilitating transcription. Although protein… CONTINUE READING