Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

@article{Parks2004SystematicGO,
  title={Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome},
  author={Annette L. Parks and Kevin R Cook and Marcia Belvin and Nicholas A Dompe and Robert Fawcett and Kari A. Huppert and Lory R Tan and Christopher G. Winter and Kevin P Bogart and Jennifer E Deal and Megan E Deal-Herr and Deanna Grant and Marie C Marcinko and Wesley Y. Miyazaki and Stephanie I. Robertson and Kenneth James Shaw and Mariano Tabios and Valentina Semenovna Vysotskaia and Lora Z. Zhao and Rachel S Andrade and Kyle A. Edgar and Elizabeth Howie and Keith Killpack and Brett Milash and Amanda L Norton and Doua Thao and Kellie L. Whittaker and Millicent A Winner and Lori A. Friedman and Jonathan S. Margolis and Matthew A Singer and Casey C. Kopczynski and Daniel F. Curtis and Thomas C. Kaufman and Gregory D. Plowman and Geoffrey M. Duyk and Helen L Francis-Lang},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={288-292}
}
In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most widely used deletions were generated by irradiation or chemical mutagenesis. These methods are labor-intensive, generate random breakpoints and result in unwanted secondary mutations that can confound phenotypic analyses. Most of the existing deletions are large, have molecularly undefined endpoints and are maintained in genetically complex… CONTINUE READING
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