Systematic exploration of the ciliary protein landscape by large-scale affinity proteomics

Abstract

Objective Mutations in different ciliopathy-associated genes often result in overlapping clinical phenotypes, which can in part be explained by disruption of overlapping functional protein modules. In this study we conducted large-scale affinity proteomics in a systems biologybased approach to boost insights into the assembly of these ciliary modules, and their connectivity in larger functional protein networks: the ciliary protein interaction landscape. This provides an important framework to deconvolute the pathways and processes that drive ciliopathies, and to understand the general importance of ciliary function for cellular homeostasis.

DOI: 10.1186/2046-2530-4-S1-P89

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Cite this paper

@inproceedings{Boldt2015SystematicEO, title={Systematic exploration of the ciliary protein landscape by large-scale affinity proteomics}, author={Karsten Boldt and Jeroen van Reeuwijk and Q Lu and Konstantinos Koutroumpas and Nicola Horn and Sander van Beersum and Yves Texier and TM Nguyen and J R Willer and Nicholas Katsanis and François K{\'e}p{\`e}s and R. Russell and Marius Ueffing and Rachel Roepman}, booktitle={Cilia}, year={2015} }