Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli

@inproceedings{Schuetz2007SystematicEO,
  title={Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli},
  author={Robert Schuetz and Lars Kuepfer and Uwe Sauer},
  booktitle={Molecular systems biology},
  year={2007}
}
To which extent can optimality principles describe the operation of metabolic networks? By explicitly considering experimental errors and in silico alternate optima in flux balance analysis, we systematically evaluate the capacity of 11 objective functions combined with eight adjustable constraints to predict (13)C-determined in vivo fluxes in Escherichia coli under six environmental conditions. While no single objective describes the flux states under all conditions, we identified two sets of… CONTINUE READING

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