Systematic evaluation of multiple immune markers reveals prognostic factors in ovarian cancer.

@article{Santoiemma2016SystematicEO,
  title={Systematic evaluation of multiple immune markers reveals prognostic factors in ovarian cancer.},
  author={Phillip P. Santoiemma and Carolina Mart{\'i}nez Reyes and Liping Wang and Mike W McLane and Michael D. Feldman and Janos L Tanyi and Daniel James Powell},
  journal={Gynecologic oncology},
  year={2016},
  volume={143 1},
  pages={
          120-127
        }
}
OBJECTIVE Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Several factors prognostic for survival have been identified including the presence of certain lymphocyte markers. Tumor-infiltrating lymphocytes (TILs), particularly cytotoxic CD8+ TILs, have been shown to be most favorable for prognosis in ovarian cancer, although other immune cells including CD3+ T-cells, CD4+ T-cells, and B-cells have also demonstrated survival benefits. Although data for these markers… CONTINUE READING
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