Systematic dissection of genomic features determining transcription factor binding and enhancer function.

@article{Grossman2017SystematicDO,
  title={Systematic dissection of genomic features determining transcription factor binding and enhancer function.},
  author={Sharon R Grossman and Xiaolan Zhang and Li Chun Wang and Jesse M. Engreitz and Alexandre Melnikov and Peter Rogov and Ryan Tewhey and Alina Isakova and Bart Deplancke and Bradley E. Bernstein and Tarjei S. Mikkelsen and Eric S. Lander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 7},
  pages={E1291-E1300}
}
Enhancers regulate gene expression through the binding of sequence-specific transcription factors (TFs) to cognate motifs. Various features influence TF binding and enhancer function-including the chromatin state of the genomic locus, the affinities of the binding site, the activity of the bound TFs, and interactions among TFs. However, the precise nature and relative contributions of these features remain unclear. Here, we used massively parallel reporter assays (MPRAs) involving 32,115… CONTINUE READING
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