Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655

@article{Gao2018SystematicDO,
  title={Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655},
  author={Ye Gao and James T. Yurkovich and Sang Woo Seo and Ilyas Kabimoldayev and Andreas Dr{\"a}ger and Ke Chen and Anand V. Sastry and Xin Fang and Nathan Mih and Laurence Yang and Johannes Eichner and Byung-Kwan Cho and Donghyuk Kim and Bernhard O. Palsson},
  journal={Nucleic Acids Research},
  year={2018},
  volume={46},
  pages={10682 - 10696}
}
Transcriptional regulation enables cells to respond to environmental changes. Yet, among the estimated 304 candidate transcription factors (TFs) in Escherichia coli K-12 MG1655, 185 have been experimentally identified and only a few tens of them have been fully characterized by ChIP methods. Understanding the remaining TFs is key to improving our knowledge of the E. coli transcriptional regulatory network (TRN). Here, we developed an integrated workflow for the computational prediction and… 
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