Systematic discovery of new genes in the Saccharomyces cerevisiae genome.

  title={Systematic discovery of new genes in the Saccharomyces cerevisiae genome.},
  author={Marco M Kessler and Qiandong Zeng and Sarah B. Hogan and Robin Cook and Arturo J. Morales and Guillaume Cottarel},
  journal={Genome research},
  volume={13 2},
We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for small open reading frames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases… CONTINUE READING
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