Systematic comparison of sporadic and syndromic pancreatic islet cell tumors.

Abstract

Pancreatic islet cell tumors (ICTs) occur as sporadic neoplasias or as a manifestation of multiple endocrine neoplasia type 1 (MEN1) and von Hippel-Lindau disease (VHL). Molecular classification of ICTs is mandatory for timely diagnosis and surveillance. Systematic comparison of VHL-ICTs and sporadic ICTs has been lacking. Our registry-based approaches used the German NET-Registry with 259 patients with neuroendocrine tumors (NETs), who were primarily diagnosed with NETs, and the German VHL-Registry with 485 molecular genetically confirmed patients who had undergone magnetic resonance imaging or computed tomography of the abdomen. All patients provided blood DNA for testing of the MEN1 and VHL genes for intragenic mutations and large deletions. In the NET-Registry, 9/101 patients (8.9%) with ICTs had germline mutations, 8 in MEN1 and 1 in VHL. In the VHL-Registry, prevalence of NETs was 52/487 (10.6%), and all were ICTs. Interestingly, of those with VHL p.R167W, 47% developed ICTs, compared to 2% of those with p.Y98H. In total, there were 92 truly sporadic, i.e. mutation-negative ICT patients. Comparing these with the 53 VHL-ICT patients, the statistically significant differences were predominance of female gender (P=0.01), multifocal ICTs (P=0.0029), and lower malignancy rate (P<0.001) in VHL-ICTs compared to sporadic cases. VHL was prevalent in <0.5% of NETs, while NETs occur in ∼10% of VHL, virtually exclusively as ICTs, which are rarely the first presentation. Patients with NETs should not be subjected to genetic testing of the VHL gene, unless they have multifocal ICTs, other VHL-associated tumors, and/or a family history for VHL.

DOI: 10.1677/ERC-10-0037

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@article{Erlic2010SystematicCO, title={Systematic comparison of sporadic and syndromic pancreatic islet cell tumors.}, author={Zoran Erlic and Ursula Ploeckinger and Alberto Casc{\'o}n and Michael Marcus Hoffmann and Laura von Duecker and Aurelia Winter and Gerit Kammel and Janina Bacher and Maren Sullivan and Berend H. Isermann and Lars Fischer and Andreas Raffel and Wolfram Trudo Knoefel and Matthias Schott and Tobias Baumann and Oliver Schaefer and Tobias Keck and Richard Paul Baum and Ioana N Milos and Mihaela Muresan and Mariola Pęczkowska and Andrzej A Januszewicz and Kenko Cupisti and Anke Toenjes and Mathias Fasshauer and Jan Michael Langrehr and Peter von Wussow and Abbas Agaimy and G{\"{u}nter Schlimok and Regina Lamberts and Thorsten Wiech and Kurt Werner Schmid and Alexander Weber and Mercedes P. N{\'u}{\~n}ez and Mercedes Robledo and Charis Eng and Hartmut P. H. Neumann}, journal={Endocrine-related cancer}, year={2010}, volume={17 4}, pages={875-83} }