Systematic characterization of protein-DNA interactions

  title={Systematic characterization of protein-DNA interactions},
  author={Zhi Xie and Shaohui Hu and Jiang Qian and Seth Blackshaw and H. A. Zhu},
  journal={Cellular and Molecular Life Sciences},
Sequence-specific protein-DNA interactions (PDIs) are critical for regulating many cellular processes, including transcription, DNA replication, repair, and rearrangement. We review recent experimental advances in high-throughput technologies designed to characterize PDIs and discuss recent studies that use these tools, including ChIP-chip/seq, SELEX-based approaches, yeast one-hybrid, bacterial one-hybrid, protein binding microarray, and protein microarray. The results of these studies have… CONTINUE READING


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