Systematic bias in high-throughput sequencing data and its correction by BEADS

  title={Systematic bias in high-throughput sequencing data and its correction by BEADS},
  author={M Cheung and Thomas A. Down and Isabel J Latorre and Julie Ahringer},
  booktitle={Nucleic acids research},
Genomic sequences obtained through high-throughput sequencing are not uniformly distributed across the genome. For example, sequencing data of total genomic DNA show significant, yet unexpected enrichments on promoters and exons. This systematic bias is a particular problem for techniques such as chromatin immunoprecipitation, where the signal for a target factor is plotted across genomic features. We have focused on data obtained from Illumina's Genome Analyser platform, where at least three… CONTINUE READING
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