Systematic assessment of microneedle injection into the mouse cornea

@inproceedings{Matthaei2012SystematicAO,
  title={Systematic assessment of microneedle injection into the mouse cornea},
  author={Mario Matthaei and Huan Meng and Imran Ahmed Bhutto and Qingguo Xu and Edwin Boelke and Justin Hanes and Albert S. Jun},
  booktitle={European journal of medical research},
  year={2012}
}
BACKGROUND Corneal intrastromal injection is an important mode of gene-vector application to subepithelial layers. In a mouse model, this procedure is substantially complicated by the reduced corneal dimensions. Furthermore, it may be difficult to estimate the corneal area reached by the volume of a single injection. This study aimed to investigate intrastromal injections into the mouse cornea using different microneedles and to quantify the effect of injecting varying volumes. A reproducible… CONTINUE READING
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