Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease.

@article{Zuccato2008SystematicAO,
  title={Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease.},
  author={Chiara Zuccato and Manuela Marullo and Paola Conforti and Marcy E. MacDonald and Marzia Tartari and Elena Cattaneo},
  journal={Brain pathology},
  year={2008},
  volume={18 2},
  pages={225-38}
}
One cardinal feature of Huntington's disease (HD) is the degeneration of striatal neurons, whose survival greatly depends on the binding of cortical brain-derived neurotrophic factor (BDNF) with high-affinity (TrkB) and low-affinity neurotrophin receptors [p75 pan-neurotrophin receptor (p75(NTR))]. With a few exceptions, results obtained in HD mouse models demonstrate a reduction in cortical BDNF mRNA and protein, although autopsy data from a limited number of human HD cortices are conflicting… CONTINUE READING
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