Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.

@article{Dlken2010SystematicAO,
  title={Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.},
  author={Lars D{\"o}lken and Georg Malterer and Florian Erhard and Sheila Isabella Karola Kothe and Caroline C. Friedel and Guillaume Suffert and Lisa Marcinowski and Natalie Motsch and Stephanie Barth and Michaela Beitzinger and Diana Lieber and Susanne M Bailer and Reinhard Hoffmann and Zsolt Ruzsics and Elisabeth Kremmer and S{\'e}bastien Pfeffer and Ralf Zimmer and Ulrich Koszinowski and Friedrich A Gr{\"a}sser and Gunter Meister and Juergen Haas},
  journal={Cell host & microbe},
  year={2010},
  volume={7 4},
  pages={
          324-34
        }
}
The mRNA targets of microRNAs (miRNAs) can be identified by immunoprecipitation of Argonaute (Ago) protein-containing RNA-induced silencing complexes (RISCs) followed by microarray analysis (RIP-Chip). Here we used Ago2-based RIP-Chip to identify transcripts targeted by Kaposi's sarcoma-associated herpesvirus (KSHV) miRNAs (n = 114), Epstein-Barr virus (EBV) miRNAs (n = 44), and cellular miRNAs (n = 2337) in six latently infected or stably transduced human B cell lines. Of the six KSHV miRNA… CONTINUE READING
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