Systematic analysis of donor and isolation factor's impact on human islet yield and size distribution.

@article{Wang2013SystematicAO,
  title={Systematic analysis of donor and isolation factor's impact on human islet yield and size distribution.},
  author={Youli Wang and Kirstie K Danielson and A Ropski and Tricia A. Harvat and Barbara Barbaro and Daniel H Paushter and Meirigeng Qi and Jos{\'e} Oberholzer},
  journal={Cell transplantation},
  year={2013},
  volume={22 12},
  pages={2323-33}
}
Islet transplantation is a promising therapy for T1DM. Key factors influencing islet yield have been identified with conflicting results. In this study, we analyzed 276 isolations to identify variables for islet yield and, additionally, islet size and size distribution. Pearson correlation analyses demonstrated that BMI had a positive correlation with pancreas size, actual islet count (AIC), and islet equivalent (IEQ)/g (all p ≤ 0.009), while CIT had a negative correlation with AIC and IEQ/g… CONTINUE READING

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