Systematic Search for Recipes to Generate Induced Pluripotent Stem Cells

@inproceedings{Chang2011SystematicSF,
  title={Systematic Search for Recipes to Generate Induced Pluripotent Stem Cells},
  author={Rui Chang and Robert Shoemaker and Wei Wang},
  booktitle={PLoS Computational Biology},
  year={2011}
}
Generation of induced pluripotent stem cells (iPSCs) opens a new avenue in regenerative medicine. One of the major hurdles for therapeutic applications is to improve the efficiency of generating iPSCs and also to avoid the tumorigenicity, which requires searching for new reprogramming recipes. We present a systems biology approach to efficiently evaluate a large number of possible recipes and find those that are most effective at generating iPSCs. We not only recovered several experimentally… CONTINUE READING
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