Systematic Screens for Proteins That Interact with the Mucolipidosis Type IV Protein TRPML1

@inproceedings{Spooner2013SystematicSF,
  title={Systematic Screens for Proteins That Interact with the Mucolipidosis Type IV Protein TRPML1},
  author={Ellen Spooner and Brooke M. McLaughlin and Talya Lepow and Tyler Adam Durns and Justin R. Randall and Cameron P. Upchurch and Katherine E. Miller and Erin M. Campbell and Hanna F Fares},
  booktitle={PloS one},
  year={2013}
}
Mucolipidosis type IV is a lysosomal storage disorder resulting from mutations in the MCOLN1 gene, which encodes the endosomal/lysosomal Transient Receptor Potential channel protein mucolipin-1/TRPML1. Cells isolated from Mucolipidosis type IV patients and grown in vitro and in in vivo models of this disease both show several lysosome-associated defects. However, it is still unclear how TRPML1 regulates the transport steps implicated by these defects. Identifying proteins that associate with… CONTINUE READING

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