Systematic Review of Randomized Controlled Trials of Misoprostol to Prevent Postpartum Hemorrhage

@article{Villar2002SystematicRO,
  title={Systematic Review of Randomized Controlled Trials of Misoprostol to Prevent Postpartum Hemorrhage},
  author={Jos{\'e} Villar and Ahmet Metin G{\"u}lmezoglu and G Justus Hofmeyr and Fatu Forna},
  journal={Obstetrics \& Gynecology},
  year={2002},
  volume={100},
  pages={1301–1312}
}
OBJECTIVE To assess the effects of prophylactic misoprostol use in the third stage of labor compared with injectable uterotonics or placebo or no treatment. DATA SOURCES The Cochrane Pregnancy and Childbirth Group trials register; the Cochrane Library, including databases such as the database of systematic reviews and the Cochrane Controlled Trials Register; and MEDLINE were searched. Researchers in the field were also contacted. The date of the latest search was March 1, 2002. METHODS OF STUDY… Expand
Misoprostol for prevention and treatment of postpartum haemorrhage: A systematic review.
TLDR
The use of misoprostol was not associated with any significant reduction in the incidence of PPH, and specialised investigations of its dose and routes of administration for clinically significant effects and acceptable side effects are warranted. Expand
Rectal misoprostol versus oxytocin in the management of the third stage of labour.
TLDR
The utility of misoprostol as a safe and effective uterotonic for use in the rural and remote areas of developing nations where other pharmacologic agents may be less feasible is confirmed. Expand
Misoprostol in the treatment of postpartum haemorrhage in addition to routine management: a placebo randomised controlled trial
TLDR
This randomised controlled trial compared misoprostol 600 μg (200 μg orally and 400 μg sublingually) with placebo in the treatment of postpartum haemorrhage in addition to routine treatment. Expand
Oral misoprostol versus oxytocin in the management of the third stage of labour.
TLDR
Routine use of oral misoprostol 800 microg appears to be as effective as 10 IU parenteral oxytocin in minimizing blood loss during the third stage of labour, as determined by change in hemoglobin concentration. Expand
Buccal misoprostol to prevent hemorrhage at cesarean delivery: a randomized study.
TLDR
Buccal misoprostol reduces the need for additional uterotonic agents during cesarean delivery, and there was not a difference between the groups in the incidence of postpartum hemorrhage or a difference in preoperative and postoperative hemoglobin level. Expand
Rectal versus oral misoprostol for active management of third stage of labor: a randomized controlled trial
TLDR
Rectal misoprostol is effective in the management of third stage of labor, and with a significant decrease in side effects, and lesser dose and other routes could be explored in the future. Expand
Efficacy of Rectal Misoprostol for Prevention of Postpartum Hemorrhage
TLDR
Rectal misoprostol as an uterotonic drug can decrease postpartum hemorrhage and also can prevent from decrease of hemoglobin as compared to oxytocin. Expand
Buccal Misoprostol to Decrease Blood Loss After Vaginal Delivery: A Randomized Trial
TLDR
Buccal misoprostol at cord clamping is no more effective than placebo in reducing postpartum hemorrhage. Expand
Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage.
  • Dean Leduc, V. Senikas, A. Lalonde
  • Medicine
  • Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • 2009
TLDR
These guidelines are an update from the previous Society of Obstetricians and Gynaecologists of Canada clinical practice guideline on PPH and provide guidelines to assist clinicians in the prevention and management of PPH. Expand
Sublingual misoprostol for the prevention of postpartum hemorrhage.
TLDR
Postpartum use of 600 microg misoprostol by sublingual route has a comparable effect in reducing PPH, as that of rectal route. Expand
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References

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Rectal misoprostol in the prevention of postpartum hemorrhage: a placebo-controlled trial.
TLDR
Postpartum use of 400 microg rectal misoprostol was well tolerated and associated with a statistically nonsignificant trend toward less postpartum hemorrhage, which may have reduced the potential of the study to detect differences between the groups. Expand
Misoprostol versus oxytocin in the third stage of labor
TLDR
Oral misoprostol is as effective as intramuscular oxytocin in the prevention of PPH and has potential in reducing the high incidence of P PH in developing countries. Expand
Oral misoprostol for third stage of labor: a randomized placebo-controlled trial.
TLDR
Oral misoprostol administered in the third stage of labor reduced post partum blood loss and might be effective in reducing incidence of postpartum hemorrhage. Expand
WHO multicentre randomised trial of misoprostol in the management of the third stage of labour
TLDR
A multicentre, double-blind, randomised controlled trial to determine whether oral misoprostol is as effective as oxytocin during the third stage of labour and the use of additional uterotonics without an unacceptable level of side-effects. Expand
Side-effects of oral misoprostol in the third stage of labour--a randomised placebo-controlled trial.
TLDR
This study has shown the association of postpartum oral misoprostol 600 micrograms with shivering, pyrexia and hypertension, and possible effects on blood loss may have been obscured by the lesser use of additional oxytocics in the misop frostol group. Expand
Randomized comparison of rectalmisoprostol with Syntometrine for management of third stage of labor
TLDR
The objective of this study was to randomly compare the effectiveness of rectal misoprostol with Syntometrine in the management of the third stage of labor and found that there was a significant difference in the pre-delivery blood pressure of the two groups. Expand
Randomized comparison of rectal misoprostol with Syntometrine for management of third stage of labor.
TLDR
There was a significant difference in the pre-delivery blood pressure of the two groups because of the non-protocol exclusion of women with elevated blood pressure allocated to receive Syntometrine. Expand
Misoprostol for prevention of postpartum hemorrhage
TLDR
Misoprostol administered as a micro‐enema, 400 μg in 5 ml of saline during the third stage of labor, appears to be as effective as oxytocin 10 IU, i.m., but misop Frostol produced more side effects than oxytoc in a double blind, randomized, clinical trial. Expand
Prophylactic syntometrine versus oxytocin for delivery of the placenta.
TLDR
The use of the combination preparation syntometrine (oxytocin and ergometrine) as part of the routine active management of the third stage of labour appears to be associated with a statistically significant reduction in the risk of postpartum haemorrhage when compared to oxytocin where blood loss is less than 1000ml. Expand
A Randomized Clinical Trial Comparing Oral Misoprostol With Synthetic Oxytocin or Syntometrine in the Third Stage of Labour
TLDR
Oral misoprostol 400μg is significantly less effective than the traditional intramuscular uterotonic agents currently used and therefore cannot be considered as a viable option to these agents in the management of the third stage of labour. Expand
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