Systematic Review of Oral Treatments for Seborrheic Dermatitis

@article{Gupta2014SystematicRO,
  title={Systematic Review of Oral Treatments for Seborrheic Dermatitis},
  author={A.K. Gupta and Matthew Richardson and Maryse Paquet},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2014},
  volume={28}
}
Seborrheic dermatitis (SD) is normally treated with topical corticosteroids and antifungals. [] Key Method MEDLINE and Embase databases and the reference listings of publications were searched for any publication using oral treatment for SD. The quality of the included publications was assessed using a modified 27 item checklist by Downs and Black. Twenty-one publications (randomized controlled trials, open trials and case reports) covering eight oral therapies (itraconazole, terbinafine, fluconazole…

Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review

TLDR
Promiseb®, desonide, mometasone furoate, and pimecrolimus were found to be effective topical treatments for facial SD, as they had the lowest recurrence rate, highest clearance rate, and the lowest severity scores (e.g., erythema, scaling, and pruritus), respectively.

The Efficacy and Safety of Pimecrolimus in Patients With Facial Seborrheic Dermatitis: A Systematic Review of Randomized Controlled Trials

TLDR
Pimecrolimus was found to be an effective topical treatment for facial SD, as it showed considerable desirable control of the symptoms in patients with facial SD clinically, in addition to a lower recurrence or relapsing rates; however, it had more side effects compared to other topical treatments, but the side effects were mild and tolerable.

Oral fluconazole in scalp seborrheic dermatitis in Albania

TLDR
Oral fluconazole was safe and beneficial, especially in patients with moderate or severe forms of scalp seborrheic dermatitis, especially during the treatment of scalp lesions in Albania.

To Compare the Efficacy of Different Therapeutic Agents in Treatment of Seborrheic Dermatitis

TLDR
It can be inferred from the results that topical ketoconazole still remains the most effective and preferred antifungal drug for the treatment of SD and steroid sparing immunemodulator topical tacrolimus had a statistical advantage over conventional topical steroid application.

A Meta-Analysis on the Effectiveness of Sertaconazole 2% Cream Compared with Other Topical Therapies for Seborrheic Dermatitis

TLDR
Treating patients with seborrheic dermatitis with sertaconazole 2% cream may represent an efficient alternative therapy for patients with SD.

Low-Dose Isotretinoin for Seborrhoeic Dermatitis

  • M. Rademaker
  • Medicine
    Journal of cutaneous medicine and surgery
  • 2017
TLDR
A retrospective review of patients with seborrhoeic dermatitis treated with isotretinoin over a 5-year period found no significant difference in response, as determined by the presence of concomitant disease (acne, folliculitis, or rosacea).

Efficacy of Oral Itraconazole in the Treatment and Relapse Prevention of Moderate to Severe Seborrheic Dermatitis: A Randomized, Placebo-Controlled Trial

TLDR
Itraconazole is not only an effective and safe therapy for controlling exacerbations of SD but may also be used as maintenance therapy to prevent disease recurrence.

Features of management of patients with seborrheic dermatitis

TLDR
In the treatment of persistent and long-term forms of seborrheic dermatitis, systemic antifungal agents and systemic retinoids are used, which allow for a long time to achieve regression of skin rashes and significantly improve the quality of life of the patient.

Systemic isotretinoin in treatment of severe seborrheic dermatitis

TLDR
The use of low doses of systemic isotretinoin proved to be an effective method of drug therapy for severe seborrheic dermatitis and demonstrated a distinct improvement in the quality of life of patients.

Topical antifungals used for treatment of seborrheic dermatitis

TLDR
Various topical antifungals available for use in seborrheic dermatitis of scalp, face and flexural areas are discussed, their efficacy and safety profiles from relevant studies available in the literature along with upcoming novel delivery methods to enhance the efficacy of these drugs.
...

References

SHOWING 1-10 OF 36 REFERENCES

Treatment of moderate to severe facial seborrheic dermatitis with itraconazole: an open non-comparative study.

TLDR
Initial treatment with itraconazole was beneficial in patients with moderate to severe seborrheic dermatitis and significant improvement was reported in three clinical parameters: erythema, scaling, itching.

A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral Anti-Malassezia Agent

TLDR
A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis, and the density in Malassezia present on lesional skin is first decreased, followed by clearing of the clinical signs.

Oral Terbinafine in the Treatment of Multi-Site Seborrheic Dermatitis: A Multicenter, Double-Blind Placebo-Controlled Study

TLDR
It is shown that terbinafine is significantly more effective than placebo in reducing the severity of SD lesions in non-exposed sites and standard treatment regimens in different types of patients with SD are warranted.

Fluconazole and its place in the treatment of seborrheic dermatitis--new therapeutic possibilities.

TLDR
Fluconazole treatment in patients with seborrheic dermatitis proves to be successful, effective and safe.

ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS

TLDR
The anti-inflammatory activity of oral itraconazole suggests that it should be the first-line therapy in severe SD.

The response of seborrhoeic dermatitis to ketoconazole

TLDR
It is concluded that Pityrosporum yeast infection is the immediate cause of seborrhoeic dermatitis and that dandruff is its mildest manifestation.

Seborrhoeic dermatitis: current treatment practices

TLDR
Clinical trial data is reviewed on treatment options available for Seborrhoeic dermatitis, a recurrent, chronic inflammation of the skin that occurs on sebum rich areas such as the face, scalp and chest, characterised by red scaly lesions.

Role of Antifungal Agents in the Treatment of Seborrheic Dermatitis

TLDR
Antifungal therapy reduces the number of yeasts on the skin, leading to an improvement in seborrheic dermatitis, with a wide availability of preparations, including creams, shampoos, and oral formulations.

Seborrheic dermatitis flare in a Dutch male due to commensal Malassezia furfur overgrowth.

TLDR
This is a case of seborrheic dermatitis (SD) barbae from which Malassezia furfur (M. furfur) was isolated from skin scrapings and 7 days later therapy was terminated and no recurrence was noted after one week follow-up since the cessation of treatment.

Seborrheic dermatitis: an update.

TLDR
Current knowledge on the etiopathogenesis and therapy of adult seborrheic dermatitis is summarized in a review of treatment modalities available.