Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

@inproceedings{Barbie2009SystematicRI,
  title={Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1},
  author={David Allen Barbie and Pablo Tamayo and Jesse S Boehm and So Young Kim and Susan Elizabeth Moody and Ian Frederick Dunn and Tiffany E. Taylor and P Ardha Sandy and Etienne Meylan and Claudia Scholl and Stefan Fr{\"o}hling and Edmond Mankee Chan and Martin L Sos and Kathrin Michel and Craig H. Mermel and Serena J. Silver and Barbara A. Weir and Jan H Reiling and Qing Hai Sheng and Piyush B. Gupta and Raymond Couric Wadlow and Hanh Nguyen Hieu Le and Sebastian Hoersch and Ben S. Wittner and Sridhar Ramaswamy and David Livingston and David M. Sabatini and Matthew L Meyerson and Roman K. Thomas and Eric S. Lander and Jill P. Mesirov and David E Root and Dwight Gary Gilliland and Tyler 8 Jacks and William C. Hahn},
  booktitle={Nature},
  year={2009}
}
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has remained refractory to this approach. A complementary strategy for targeting KRAS is to identify gene products that, when inhibited, result in cell death only in the presence of an oncogenic allele… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 633 CITATIONS, ESTIMATED 74% COVERAGE

Dissection of TBK 1 signaling via phosphoproteomics in lung cancer cells

Jae-Young Kima, Eric A. Welshb, +10 authors Eric B. Hauraa
  • 2013
VIEW 12 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma.

  • Translational cancer research
  • 2013
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets.

Frédéric Pont, Marie Tosolini, Jean J Fournié
  • Nucleic acids research
  • 2019
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 48 Highly Influenced Citations

  • Averaged 63 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

J Luo
  • Cell
  • 2009

Highly parallel identification of essential genes in cancer cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008