Systematic Literature Review of Adjunctive Anti-Epileptic Drug Trials In Patients With Primary Generalized Tonic-Clonic Seizures Illustrates Changes in Standard of Care Over 12-20 Years.


• Four anti-epileptic drugs (AEDs) have been approved for the adjunctive treatment of primary generalized tonic-clonic seizures (PGTCS) in adults: topiramate [TPM], lamotrigine [LTG]/ lamotrigine-XR [LTG-XR], levetiracetam [LEV], and perampanel [PER]. • Five randomized-controlled trials were conducted to support these approvals [1-5]. Lamotrigine-XR applies… (More)
DOI: 10.1016/j.jval.2015.09.2743


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