Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

  title={Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity},
  author={Leila M. Luheshi and Gian Gaetano Tartaglia and Ann-Christin Brorsson and Amol P Pawar and Ian E Watson and Fabrizio Chiti and Michele Vendruscolo and David A. Lomas and Christopher M. Dobson and Damian C Crowther},
  journal={PLoS Biology},
  pages={333 - 366}
Protein aggregation into amyloid fibrils and protofibrillar aggregates is associated with a number of the most common neurodegenerative diseases. We have established, using a computational approach, that knowledge of the primary sequences of proteins is sufficient to predict their in vitro aggregation propensities. Here we demonstrate, using rational mutagenesis of the Abeta42 peptide based on such computational predictions of aggregation propensity, the existence of a strong correlation… CONTINUE READING
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