Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer

@article{Kim2013SystematicIO,
  title={Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer},
  author={Hyun Seok Kim and Saurabh Mendiratta and Jiyeon Kim and Chad V Pecot and Jill Everland Larsen and Iryna O. Zubovych and Bo Yeun Seo and Jimi Kim and Banu Eskiocak and Hannah Chung and Elizabeth McMillan and Sherry Yen-Yao Wu and Jef K De Brabander and Kakajan Komurov and Jason E. Toombs and Shuguang Wei and Michael Peyton and Noelle S Williams and Adi F. Gazdar and Bruce A. Posner and Rolf A Brekken and Anil Sood and Ralph J DeBerardinis and Michael G. Roth and John D. Minna and Michael A. White},
  journal={Cell},
  year={2013},
  volume={155},
  pages={552-566}
}
Context-specific molecular vulnerabilities that arise during tumor evolution represent an attractive intervention target class. However, the frequency and diversity of somatic lesions detected among lung tumors can confound efforts to identify these targets. To confront this challenge, we have applied parallel screening of chemical and genetic perturbations within a panel of molecularly annotated NSCLC lines to identify intervention opportunities tightly linked to molecular response indicators… CONTINUE READING