Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair

  title={Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair},
  author={Christine Katrin Schmidt and Yaron Galanty and Matylda Sczaniecka-Clift and Julia A Coates and Satpal Jhujh and Mukerrem Demir and Matthew Cornwell and Petra Beli and Stephen P. Jackson},
  journal={Nature Cell Biology},
Ubiquitylation is crucial for proper cellular responses to DNA double-strand breaks (DSBs). If unrepaired, these highly cytotoxic lesions cause genome instability, tumorigenesis, neurodegeneration or premature ageing. Here, we conduct a comprehensive, multilayered screen to systematically profile all human ubiquitin E2 enzymes for impacts on cellular DSB responses. With a widely applicable approach, we use an exemplary E2 family, UBE2Ds, to identify ubiquitylation-cascade components downstream… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 23 extracted citations


Publications referenced by this paper.
Showing 1-10 of 12 references

RIF 1 is essential for 53 BP 1dependent nonhomologous end joining and suppression of DNA double - strand break resection

J. R. Chapman
Mol . Cell • 2013

Mammalian SUMO E 3ligases PIAS 1 and PIAS 4 promote responses to DNA double - strand breaks

Y. Galanty
Nature • 2009

Nuclear ataxiatelangiectasia mutated ( ATM ) mediates the cellular response to DNA double strand breaks in human neuronlike cells

S. Biton
J . Biol . Chem . • 2006

Similar Papers

Loading similar papers…