Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair

@article{Schmidt2015SystematicES,
  title={Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair},
  author={Christine Katrin Schmidt and Yaron Galanty and Matylda Sczaniecka-Clift and Julia A Coates and Satpal Jhujh and Mukerrem Demir and Matthew Cornwell and Petra Beli and Stephen P. Jackson},
  journal={Nature Cell Biology},
  year={2015},
  volume={17},
  pages={1458-1470}
}
Ubiquitylation is crucial for proper cellular responses to DNA double-strand breaks (DSBs). If unrepaired, these highly cytotoxic lesions cause genome instability, tumorigenesis, neurodegeneration or premature ageing. Here, we conduct a comprehensive, multilayered screen to systematically profile all human ubiquitin E2 enzymes for impacts on cellular DSB responses. With a widely applicable approach, we use an exemplary E2 family, UBE2Ds, to identify ubiquitylation-cascade components downstream… CONTINUE READING

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