Systematic Dissection of the Sequence Determinants of Gene 3’ End Mediated Expression Control

Abstract

The 3'end genomic region encodes a wide range of regulatory process including mRNA stability, 3' end processing and translation. Here, we systematically investigate the sequence determinants of 3' end mediated expression control by measuring the effect of 13,000 designed 3' end sequence variants on constitutive expression levels in yeast. By including a… (More)
DOI: 10.1371/journal.pgen.1005147

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