Systematic Clustering of Transcription Start Site Landscapes

  title={Systematic Clustering of Transcription Start Site Landscapes},
  author={Xiaobei Zhao and Eivind Valen and Brian J. Parker and Albin Sandelin},
  booktitle={PloS one},
Genome-wide, high-throughput methods for transcription start site (TSS) detection have shown that most promoters have an array of neighboring TSSs where some are used more than others, forming a distribution of initiation propensities. TSS distributions (TSSDs) vary widely between promoters and earlier studies have shown that the TSSDs have biological implications in both regulation and function. However, no systematic study has been made to explore how many types of TSSDs and by extension core… CONTINUE READING
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