Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire

@inproceedings{Lavinder2014SystematicCA,
  title={Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire},
  author={Jason J. Lavinder and Kam Hon Hoi and Sai T. Reddy and Yariv Wine and George D. Georgiou},
  booktitle={PloS one},
  year={2014}
}
Rabbits have been used extensively as a model system for the elucidation of the mechanism of immunoglobulin diversification and for the production of antibodies. We employed Next Generation Sequencing to analyze Ig germline V and J gene usage, CDR3 length and amino acid composition, and gene conversion frequencies within the functional (transcribed) IgG repertoire of the New Zealand white rabbit (Oryctolagus cuniculus). Several previously unannotated rabbit heavy chain variable (VH) and light… CONTINUE READING
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