Systematic Analysis of the Determinants of Gene Expression Noise in Embryonic Stem Cells.

@article{Faure2017SystematicAO,
  title={Systematic Analysis of the Determinants of Gene Expression Noise in Embryonic Stem Cells.},
  author={Andre J. Faure and J{\"o}rn Matthias Schmiedel and Ben Lehner},
  journal={Cell systems},
  year={2017},
  volume={5 5},
  pages={471-484.e4}
}
Isogenic cells in a common environment show substantial cell-to-cell variation in gene expression, often referred to as "expression noise." Here, we use multiple single-cell RNA-sequencing datasets to identify features associated with high or low expression noise in mouse embryonic stem cells. These include the core promoter architecture of a gene, with CpG island promoters and a TATA box associated with low and high noise, respectively. High noise is also associated with "conflicting… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…