System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells.

@article{Kizhatil2002SystemYL,
  title={System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells.},
  author={Krishnakumar Kizhatil and Lorraine M Albritton},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 6},
  pages={
          C1784-94
        }
}
We report here that the system y+ cationic amino acid transporter ATRC1 localized to clusters within the basolateral membrane of polarized Madin-Darby canine kidney and human embryonic kidney (HEK) cells, suggesting that the transporters are restricted to discrete membrane microdomains in epithelial cells. Based on solubility in nonionic detergents, two populations of ATRC1 molecules existed: approximately half of the total ATRC1 in HEK cells associated with the actin membrane cytoskeleton… Expand
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