System-wide Perturbation Analysis with Nearly Complete Coverage of the Yeast Proteome by Single-shot Ultra HPLC Runs on a Bench Top Orbitrap*

@inproceedings{Nagaraj2012SystemwidePA,
  title={System-wide Perturbation Analysis with Nearly Complete Coverage of the Yeast Proteome by Single-shot Ultra HPLC Runs on a Bench Top Orbitrap*},
  author={Nagarjuna Nagaraj and Nils Alexander Kulak and Juergen Cox and Nadin Neuhauser and Korbinian Mayr and Ole Hoerning and Ole Vorm and Matthias Mann},
  booktitle={Molecular & cellular proteomics : MCP},
  year={2012}
}
Yeast remains an important model for systems biology and for evaluating proteomics strategies. In-depth shotgun proteomics studies have reached nearly comprehensive coverage, and rapid, targeted approaches have been developed for this organism. Recently, we demonstrated that single LC-MS/MS analysis using long columns and gradients coupled to a linear ion trap Orbitrap instrument had an unexpectedly large dynamic range of protein identification (Thakur, S. S., Geiger, T., Chatterjee, B… CONTINUE READING
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