System-wide Mapping of Activated Circuitry in Experimental Systemic Inflammatory Response Syndrome.

@article{Gharib2016SystemwideMO,
  title={System-wide Mapping of Activated Circuitry in Experimental Systemic Inflammatory Response Syndrome.},
  author={Sina A Gharib and Daniel Mar and Karol Bomsztyk and Oleg Denisenko and Shireesha Dhanireddy and W Conrad Liles and William A Altemeier},
  journal={Shock},
  year={2016},
  volume={45 2},
  pages={148-56}
}
Sepsis-induced multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in critically ill patients and remains impervious to most therapeutic interventions. We utilized a clinically relevant murine model of systemic inflammatory response syndrome (SIRS) during early MODS induced by ventilator-associated pneumonia to systematically delineate pathways dysregulated in lung, liver, and kidney. We focused on processes commonly activated across at-risk organs and… CONTINUE READING
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