System theoretical investigation of human epidermal growth factor receptor-mediated signalling.

@article{Zhang2008SystemTI,
  title={System theoretical investigation of human epidermal growth factor receptor-mediated signalling.},
  author={Yi Zhang and Harish Shankaran and Lee K. Opresko and Haluk Resat},
  journal={IET systems biology},
  year={2008},
  volume={2 5},
  pages={273-84}
}
The partitioning of biological networks into coupled-functional modules is being increasingly applied for developing predictive models of biological systems. This approach has the advantage that predicting a system-level response does not require a mechanistic description of the internal dynamics of each module. Identification of the input-output characteristics of the network modules and the connectivity between the modules provide the necessary quantitative representation of system dynamics… CONTINUE READING