System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae.

@article{Gresham2011SystemlevelAO,
  title={System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae.},
  author={David Gresham and Viktor M. Boer and Amy A. Caudy and Naomi Ziv and Nathan J Brandt and John D. Storey and David Botstein},
  journal={Genetics},
  year={2011},
  volume={187 1},
  pages={299-317}
}
An essential property of all cells is the ability to exit from active cell division and persist in a quiescent state. For single-celled microbes this primarily occurs in response to nutrient deprivation. We studied the genetic requirements for survival of Saccharomyces cerevisiae when starved for either of two nutrients: phosphate or leucine. We measured the survival of nearly all nonessential haploid null yeast mutants in mixed populations using a quantitative sequencing method that estimates… CONTINUE READING
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