System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection.

@article{Aerts2008SystemIT,
  title={System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection.},
  author={Hugo J. W. L. Aerts and Natal A. W. van Riel and Walter H. Backes},
  journal={Magnetic resonance in medicine},
  year={2008},
  volume={59 5},
  pages={1111-9}
}
Optimization of experimental settings of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), like the contrast administration protocol, is of great importance for reliable quantification of the microcirculatory properties, such as the volume transfer-constant K(trans). Using system identification theory and computer simulations, the confounding effects of volume, rate and multiplicity of a contrast injection on the reliability of K(trans) estimation was assessed. A new tracer… CONTINUE READING